Antibiotika klasse

Vigtigste PK-PD-parameter

Krav til behandlingen

(% af dosis interval)

b-lactam

(penicilliner, cefalosporiner, carbapenemer)

T_>MIC

T_>MIC over/lig med 50 %

(dog skal også C_MAX/MIC over 10)

Fluorkinoloner

(ciprofloxacin, moxifloxacin, ofloxacin)

AUC/MIC

AUC/MIC over 100 (Gram negative bakterier)

AUC/MIC over 30 (Gram positive bakterier)

Makrolider, lincosamider

(erythromycin, roxithromycin, clarithromycin, clindamycin, etc.)

T_>MIC

T_>MIC over/lig med 50 %

Azithromycin

AUC/MIC eller C_MAX/MIC

AUC/MIC over 100 og/eller

C_MAX/MIC over 8

Aminoglykosider

(gentamicin, netilmicin,  tobramycin, etc.)

C_MAX/MIC

C_MAX/MIC over 8

Glykopeptider

(vancomycin, teicoplanin, etc.)

C_MAX/MIC og T_>MIC

T_>MIC = 100 % og

C_MIN/MIC over 8

Sulfametizol

T_>MIC

? T_>MIC over/lig med 50 %

Trimethoprim

T_>MIC

? T_>MIC over/lig med 50 %

Nitrofurantoin

AUC/MIC

? AUC/MIC over 100

Oxazolidinon

(linezolid)

AUC/MIC

AUC/MIC over 100

Tetracykliner,

(tetracycline, doxycyclin, tigecyclin, etc.)

AUC/MIC

AUC/MIC over 100

(tigecyclin, dog AUC/MIC over 12)

Rifampicin

AUC/MIC

AUC/MIC over 100

Colistin

C_MAX/MIC

C_MAX/MIC over 8

Metronidazol

C_MAX/MIC

C_MAX/MIC over 10

AmphotericinB

(amphotericinB, ambisome, abelcet)

C_MAX/MIC

C_MAX/MIC over 10

Azoler,

(fluconazol, itraconazol, voriconazol, posaconazol, etc.)

AUC/MIC

AUC/MIC over 100

Echinocandin

(caspofungin, anidulafungin, etc.)

C_MAX/MIC

C_MAX/MIC over 10